Manuscript Number : GISRRJ2032112

Review On Alzheimer's Disease; A Neurodegenerative Tauopathy

Authors(2) :-Dr. Sudhi Shrivastava, Ratnesh Kumar Soni

Alzheimer's is a slowly progressive neurodegenerative disease and is one of the most common types of dementia, which causes, degeneration of the cells in the brain. It is a major concern in older people. Pathological characterization of Alzheimer’s shows neurotic plaques and neurofibrillary tangles because of amyloid-beta peptide’s (Aβ) accumulation in the most affected area of the brain. Tau is an important microtubule-associated protein that stabilizes microtubules polymerization and regulates axonal stability thus contributing to the proper functioning of neurons. Alteration in tau, forms neurofibrillary tangles and amyloid plaques in intercellular space causing disruption in signal transmission. The molecular mechanism which causes tau aggregation is posttranslational modification. Abnormal phosphorylation is found in Alzheimer’s disease. This review describes the role of tau in stabilization and destabilization and the molecular mechanism which causes Alzheimer’s disease.

Authors and Affiliations

Dr. Sudhi Shrivastava
CMP College Allahabad, U.P.,
Ratnesh Kumar Soni
K.N. Govt. P.G. College Gyanpur Bhadohi .

Alzheimer’s disease, Tau protein, Tauopathies.

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Publication Details

Published in : Volume 3 | Issue 2 | March-April 2020
Date of Publication : 2020-04-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 136-140
Manuscript Number : GISRRJ2032112
Publisher : Technoscience Academy

ISSN : 2582-0095

Cite This Article :

Dr. Sudhi Shrivastava, Ratnesh Kumar Soni , "Review On Alzheimer's Disease; A Neurodegenerative Tauopathy", Gyanshauryam, International Scientific Refereed Research Journal (GISRRJ), ISSN : 2582-0095, Volume 3, Issue 2, pp.136-140, March-April.2020
URL : https://gisrrj.com/GISRRJ2032112

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